Trifluoroacetic acid → HCID 20672396, compound

Participants

Reaction Steps

The title compound was prepared from 50 mg (0.12 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, (4-methoxy)benzyl ester (from EXAMPLE 33, Step E) and 55 mg (015 mmol) of 4-(3-(quinoxalin-2-yl)propyl)piperidine.2 TFA (from EXAMPLE 73, Step A) using a procedure analogous to that described in EXAMPLE 71, Step A. Flash chromatography using 19:1 v/v CH2Cl2/MeOH afforded 77 mg (100%) of the title compound: 1H NMR (500 MHz) 80.83-3.36(35H), 3.81 (s, 3H), 5.11 (ABq, J=11.9, 2H), 6.89 (d, J=8.7, 2H), 7.16-7.35 (7H), 7.70-7.78 (2H), 8.03-8.10 (2H), 8.73 (s, 1H).

Provenance & Evidence