Dichloromethane methanol ammonium hydroxide → HCID 20672396, compound

Participants

Reaction Steps

The title compound was prepared from 77 mg (0.11 mmol) of 2-(R)-(3-(S)-((4-(3-(quinoxalin-2-yl)propyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, (4-methoxy)benzyl ester (from EXAMPLE 73, Step B) using a procedure analogous to that described in EXAMPLE 10, Step F. Flash chromatography using 95:5:0.5 v/v/v CH2Cl2/MeOH/NH4OH as the eluant afforded 55 mg (87%) of the title compound: 1H NMR (500 MHz) δ 0.874.00 (35H), 7.22-7.30 (5H), 7.69-7.76 (2H), 8.00-8.08 (2H), 8.70 (s, 1H); ESI-MS 555 (M+H); HPLC A: 2.27 min.

Provenance & Evidence