4-Hydroxy-4-(3-(2-naphthyl)propyl)piperidine → 2-(r)-(3-(s)-((4-Hydroxy-4-(3-(2-napthyl)propyl)piperidin-1-yl)methyl)-4-(s)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid

Participants

Role	Name	HCID	Charge
Reactant	4-Hydroxy-4-(3-(2-naphthyl)propyl)piperidine	HCID 21180775	—
Reactant	2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester	HCID 59924617	—
Product	2-(r)-(3-(s)-((4-Hydroxy-4-(3-(2-napthyl)propyl)piperidin-1-yl)methyl)-4-(s)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid	HCID 20672404	—

Reaction Steps

The title compound was prepared from 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester (from EXAMPLE 1, Step I) and 4-hydroxy-4-(3-(2-naphthyl)propyl)piperidine.HCl (from EXAMPLE 82, Step A) using procedures analogous to those described in EXAMPLE 71, Steps A and B. For the title compound: 1H NMR (500 MHz) δ 0.89-3.88 (35H), 7.22-7.77 (12H); ESI-MS 569.6 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06265434B1
Source dataset	uspto-grants-2001_07
ORD ID	ord-a8e60f58a9844f4fb30342c13c242214
Source note	uspto-grants-2001_07