4-(3-Phenylpropyl)piperidine → HCID 20672387, compound

HRID 1386738Notes

Reaction equation

HRID 1386738 reaction equation
[CH:1]([C@@H:3]1[C@@H:7]([C:8]2[CH:12]=[CH:11][S:10][CH:9]=2)[CH2:6][N:5]([C@H:13]([CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[C:14]([O:16]CC2C=CC(OC)=CC=2)=[O:15])[CH2:4]1)=O.[C:32]1([CH2:38][CH2:39][CH2:40][CH:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[C:32]1([CH2:38][CH2:39][CH2:40][CH:41]2[CH2:42][CH2:43][N:44]([CH2:1][C@@H:3]3[C@@H:7]([C:8]4[CH:12]=[CH:11][S:10][CH:9]=4)[CH2:6][N:5]([C@H:13]([CH:26]4[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)[C:14]([OH:16])=[O:15])[CH2:4]3)[CH2:45][CH2:46]2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 876784-(3-Phenylpropyl)piperidineHCID 57174546HCID 57174546, compound

Product 1

HCID 20672387HCID 20672387, compound

Procedure

The title compound was prepared from 2-(R)-(3-(R)-formyl-4-(S)-(3-thienyl)pyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, 4-methoxybenzyl ester (from EXAMPLE 90, Step A) and 4-(3-phenylpropyl)piperidine using procedures analogous to those described in EXAMPLE 1, Step J and EXAMPLE 10, Step F. For the title compound: 1H NMR (500 MHz) δ 0.85-4.20 (35H), 7.11-7.35 (81); ESI-MS 509 (M+H).

Sources & evidence

ORD record
ord-baaa90e866794975b9362a9878458956
Source dataset
uspto-grants-2001_07
Patent number
US06265434B1

Reaction notes

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