HCID 21180635, compound → HCID 57149393, compound

Participants

Reaction Steps

The title compound was prepared from 3-(R)-(t-butyldimethylsilyloxymethyl)-4-(S)-phenyl pyrrolidine (from EXAMPLE 1, Step E) and (R/S)-2-hydroxy-3-(cyclobutyl)propanoic acid (from EXAMPLE 92, Step A) using procedures analogous to those described in EXAMPLE 1, Steps G an H. The diastereomers were separated by HPLC in the second step using the following conditions: Chiralpak AD 2×25 cm column, 17:3 v/v hexanes/iPrOH, 9.0 mL/min, 220 nm) to provide the title compound.

Provenance & Evidence