HCID 131722811, compound → HCID 131722810, compound

Participants

Reaction Steps

A solution of 39 mg (0.054 mmol) 2-(R/S)-(3-(S)-((4-(3-phenylpropyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-cyclohexylmethylphosphonic acid, dibenzyl ester (from EXAMPLE 93, Step D) in 2.3 mL of MeOH was hydrogenated using 17 mg of 10% palladium on carbon under 47 psi of hydrogen gas on a Parr shaker. After TLC indicated the absence of the starting benzyl ester, the reaction was filtered through a 0.45 micron nylon membrane polypropylene filter and concentrated to give 21.1 mg (73%) of the title compound: 1H NMR (500 MHz, CD3OD) δ 0.99-3.57 (m, 35H), 6.97-7.29 (m, 10H); ESI-MS 539 (M+H); HPLC A: 2.59 min.

Provenance & Evidence