HCID 86757210, compound → HCID 20672354, compound

Participants

Reaction Steps

A mixture of 2-(R)-(3-(S)-((4-(3-(3,5-difluorophenyl)propyl) piperidin-1-yl)methyl)-4-(S)-(3-fluorophenyl)pyrrolidin-1-yl)-3-(cyclobutyl)propanoic acid, benzyl ester (from EXAMPLE 95, Step F) and 20 mg 10% palladium on carbon in MeOH (5 mL) was hydrogenated at 50 psi for 90 min. The reaction mixture was filtered though Celite, the filter cake washed with MeOH, and the filtrate concentrated to afford 31 mg (84%, two steps) of the title compound: ESI-MS 543 (M+H); HPLC A: 2.85 min.

Provenance & Evidence