4-[3-(4-Fluorophenyl)propyl]piperidine → 2-(R)-(3-(S)-((4-(3-(4-Fluorophenyl)propyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-3-(cyclobutyl)propanoic acid

Participants

Reaction Steps

The title compound was prepared from 25 mg (0.06 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-3-(cyclobutyl)propanoic acid, benzyl ester (from EXAMPLE 25, Step B) and 16 mg (0.06 mmol) of 4-(3-(4-fluorophenyl)propyl)piperidine.HCl (from EXAMPLE 96, Step B) using procedures analogous to those described in EXAMPLE 95, Steps F and G. 26 mg (81%) of the title compound was obtained: ESI-MS 507 (M+H); HPLC A: 2.69 min.

Provenance & Evidence