HCID 20672436, compound → HCID 20672339, compound

HRID 1386753Notes

Reaction equation

HRID 1386753 reaction equation
[C:1]1([CH2:7][C@H:8]([CH3:16])[CH2:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:17]([C@@H:19]1[C@@H:23]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:22][N:21]([C@H:30]([CH:43]2[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]2)[C:31]([O:33]CC2C=CC(OC)=CC=2)=[O:32])[CH2:20]1)=O>>[CH3:16][C@@H:8]([CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:17][C@@H:19]2[C@@H:23]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH2:22][N:21]([C@H:30]([CH:43]3[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]3)[C:31]([OH:33])=[O:32])[CH2:20]2)[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 20672436HCID 20672436, compoundHCID 53654320alpha-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid 4-methoxybenzyl ester

Product 1

HCID 20672339HCID 20672339, compound

Procedure

The title compound was prepared from 15 mg (0.07 mmol) of 4-(3-phenyl-2-(R)-methylpropyl)piperidine (from EXAMPLE 99, Step C) and 31 mg (0.07 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, (4-methoxy)benzyl ester (from EXAMPLE 33, Step E) using procedures analogous to those described in EXAMPLE 1, Step J and EXAMPLE 10, Step F. For the title compound: ESI-MS 517 (M+H).

Sources & evidence

ORD record
ord-b8beb7941877464fa9aed3d991032151
Source dataset
uspto-grants-2001_07
Patent number
US06265434B1

Reaction notes

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