4-(3-(3,5-Difluorophenyl)propyl)piperidine → 2-(R)-(3-(S)-((4-(3-(3,5-Difluorophenyl)propyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid

Participants

Reaction Steps

The title compound was prepared from 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester (from EXAMPLE 1, Step I) and 4-(3-(3,5-difluorophenyl)propyl)piperidine.HCl (from EXAMPLE 95, Step E) using procedures analogous to those described in EXAMPLE 1, Steps J and K. For the title compound: 1H NMR (500 MHz, CD3OD) δ 1.14-1.47 (1OH). 1.58-1.68 (6H). 1.77-1.84 (6H). 2.06 (t, J=11.0, 1H), 2.36 (d, J=12.3, 1H), 2.53-2.59 (3H). 2.75-2.81 (2H). 2.96 (d, J=10.5, 1H), 3.11 (q, J=10.5, 1H), 3.30-3.42 (3H). 3.57-3.60 (2H). 6.67-6.72 (m, 1H). 6.74-6.76 (2H). 7.25-7.28 (m, 1H). 7.34-7.89 (4H); ESI-MS 539 (M+H).

Provenance & Evidence