Hydrochloric Acid → 2-(R)-(3-(S)-((4-(3-(R)-Phenylbutyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid

Participants

Reaction Steps

The title compound was prepared from 30 mg (0.13 mmol) of 4-(3-(R)-phenylbutyl)piperidine.HCl and 50 mg (0.13 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester (from EXAMPLE 1, Step I) using procedures analogous to those described in EXAMPLE 1, Steps J and H. 36 mg (54%) of the title compound was obtained: 1H NMR (500 MHz, CD3OD) δ 0.94-1.84 (23H). 2.06-2.14 (m, 1H). 2.36-2.42 (m, 1H). 2.57-2.60 (2H). 2.74-3.02 (3H). 3.10-3.12 (m, 1H). 3.30-3.60 (7H). 7.10-7.13 (3H). 7.21-7.29 (3H), 7.34-7.39 (4H); ESI-MS 517 (M+H).

Provenance & Evidence