HCID 18187828, compound → HCID 20672371, compound

Participants

Reaction Steps

The title compound was prepared from 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester (from EXAMPLE 1, Step 1) and 4-(3-(4-cyanophenyl)propyl)piperidine×HCl (from EXAMPLE 116, Step A) using procedures analogous to those described in EXAMPLE 1, Steps J and K. For the title compound: HPLC (Zorbax SB-C8 4.6 mm×7.5 cm column, gradient elution using 10:90 v/v CH3CN/H2O+0.1% TFA to 100% CH3CN over 7.5 min, hold for 45 sec, 2.25 mL/min, 220 nm): Retention Time: 4.13 min; ESI-MS 528 (M+H).

Provenance & Evidence