反应详情

A solution of 300 mg of 1-ethoxycarbonyl-4-((benzothiazol-2-yl)methyl)piperidine (from EXAMPLE 163, Step E) in 5 mL of EtOH and 5 mL of KOH (50 wt. % solution) was refluxed for 18 h. The reaction mixture was partitioned between H2O and EtOAc. Aqueous phase was extracted with EtOAc (3×). The combined organic phases were washed with sat'd NaCl and dried over anhydrous MgSO4. Concentration afforded 180 mg of the title compound as a brown solid.

1. customThe reaction mixture was partitioned between H2O and EtOAc
2. extractionAqueous phase was extracted with EtOAc (3×)
3. washThe combined organic phases were washed with sat'd NaCl
4. dry with materialdried over anhydrous MgSO4
5. concentrationConcentration