Methyl iodide → HCID 55275333, compound

Participants

Reaction Steps

A solution of iodomethane (1.8 mL, 29.4 mmol), K2CO3 (2.4 grams, 17.6 mmol) and 2-Allyl-4,6-difluorophenol (1.0 grams, 5.9 mmol) in 20 mL acetone was refluxed overnight. The mixture was diluted with water and extracted with EtOAc. The organic layer was dried over sodium sulfate and concentrated. Flash chromatography (Hexane) afforded 0.67 g (63%) of the title compound. 1H NMR (400 MHz, CDCl3). S 3.36 (d, 21), 3.82 (s, 3H), 4.97-5.12 (m, 2H), 5.85-6.0 (m, 1H), 6.4-6.5 (m, 2H).

Provenance & Evidence