HCID 53956777, compound → HCID 20672307, compound

Participants

Reaction Steps

The title compound was prepared using procedures analogous to those described in EXAMPLE 155, Step J, substituting 2-(R)-(3-(R)-((4-(3,3-difluoro-3-(4-fluorophenyl)propyl)piperidin-1-yl methyl)-4-(S)-(3-fluorophenyl)pyrrolidin-1-yl)-3-(cyclobutyl)propanoic acid benzyl ester (from EXAMPLE 198, Step A) for 2-(R)-(3-(S)-((4-(3,3-difluoro-3-(4-fluorophenyl)propyl)piperidin-1-yl)methyl)-4-(S)-(3-fluorophenyl)pyrrolidin-1-yl)-3-(cyclobutyl)propanoic acid benzyl ester. For the title compound: 1H NMR (500 MHz, CD3OD) δ 7.49 (dd, J=9, 6, 2H), 7.35 (td, J=8, 6, 1H), 7.16 (t, J=9,22H), 7.11-7.06 (m, 2H), 7.00 (td, J=9,2, 1H), 3.76 (q, J=8, 1H), 3.72-3.62 (m, 2H), 3.44 (t, J=10, 1H), 3.36 (dd, J=9, 6, 11H), 3.21 (dd, J=11, 7, 1H), 2.92-2.73 (m, 3H), 2.50 (septet, J=8, 1H), 2.22-2.06 (m, 5H), 2.02-1.67 (m, 9H), 1.60 (bd, J=12, 2H), 1.31-1.01 (m, 5H); ESI-MS 561 (M+H); HPLC A: 2.64 min.

Provenance & Evidence