Ethyl Acetate → HCID 54442297, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 15.5 mL of 1 M sodium bis(triemthylislyl)amide in 20 ml of THF was added 2.8 g triethyl phosphonoacetate at 0° C., and stirred at 0° C. for 15 min. After the addition of 1-benzyl-piperidine-4-carbaldehyde (from Example 162, step A) in 10 mL of 1BF, the reaction was stirred at 0° C. for 15 min. The reaction was warmed up to rt and stirred for 14 hr. The mixture was diluted with 35 ml of EtOAc and washed with H2O. Aqueous phase was extracted with 2×30 mL EtOAc. The combined organic phases were washed with brine and dried over MgSO4. Concentration gave a 2.43 g of title compound as a viscous oil.

Provenance & Evidence