HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-Chloro-5-methylsulfonyloxymethyl-thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Methanesulfonic anhydride | HCID 81560 | — |
| Reactant | (2-Chloro-1,3-thiazol-5-yl)methanol | HCID 2763180 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-5-methylsulfonyloxymethyl-thiazole | HCID 21183076 | — |
Reaction Steps
1.28 g of methanesulfonic anhydride are added to 1.0 g of 2-chloro-5-hydroxymethyl-thiazole and 0.63 g of pyridine in 10 ml of tetrahydrofuran and the mixture is stirred for three hours at room temperature. Concentration of the solution yields the title compound in the form of a solid (compound 1.3). 1H-NMR (DMSO-d6, 250 MHz): s, 1H, 7.87 ppm; s, 2H, 5.52 ppm; s, 3H, 2.43 ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265585B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-1de853938b844aa8a87f671e34dab284 |
| Source note | uspto-grants-2001_07 |