Dimethylformamide → n-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide

Participants

Reaction Conditions

Reaction Steps

2.5 g of 2-chloro-5-chloromethyl-thiazole, 12 ml of dimethylformamide, 2 g of 3-methyl-4-nitroimino-perhydro-1,3,5-oxadiazine and 3.8 g of potassium carbonate are combined and the mixture is stirred for 5 hours at 50° C. The mixture is cooled to room temperature and 50 ml of water and 50 ml of dichloromethane are added. The organic phase is separated off and dried over magnesium sulfate; the solvent is evaporated off in vacuo. Purification is carried out by column chromatography on silica gel using hexane/ethyl acetate (1:1), yielding the title compound (compound 2-2).

Provenance & Evidence