HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1386828Generated: October 31, 2026
Thionyl Chloride → 5-Methyl-1,2-oxazole-4-carbonyl chloride
https://huagongshe.com/reaction/1386828
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Methylisoxazole-4-carboxylic acid | HCID 1425240 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Methyl-1,2-oxazole-4-carbonyl chloride | HCID 2759917 | — |
Reaction Steps
127.1 g (1.0 mol) of 5-methylisoxazole-4-carboxylic acid are initially introduced into 1 l of toluene, 129.8 g (1.1 mol) of thionyl chloride are added dropwise and the mixture is then heated at 80° C. for 6 h. The volume is concentrated under reduced pressure to approximately one half and the toluene solution is used directly for further reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06265588B1 |
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| Source dataset | uspto-grants-2001_07 |
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| ORD ID | ord-32e798756d954ff1b3336108b39bfc9f |
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| Source note | uspto-grants-2001_07 |
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