HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1386870Generated: November 1, 2026
Formaldehyde → N-methyl-N-(phosphonomethyl)glycine
https://huagongshe.com/reaction/1386870
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Phosphorous acid | HCID 107909 | — |
| Reactant | N-Acetyl-N-methylglycine | HCID 10975514 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-methyl-N-(phosphonomethyl)glycine | HCID 541499 | 98% |
Reaction Steps
N-acetyl sarcosine (XX)(2.0 g, 15.3 mmole), phosphorous acid (1.25 g, 15.3 mmole) were mixed with concentrated sulfuric acid (3.1 g) and water (1.7 g) then refluxed in a 120° C. oil bath. Formalin, 37% (1.4 g, 16.7 mmole) was added dropwise over 20 min. and the reaction was continued for an additional 18 h. 31P NMR analysis indicated 98% yield of (XXI) based on mmoles of (XX) charged.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06265605B1 |
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| Source dataset | uspto-grants-2001_07 |
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| ORD ID | ord-049a1b8f4b8f4164914ad0e6f4799313 |
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| Source note | uspto-grants-2001_07 |
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