Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | N-((9H-Fluoren-9-ylmethoxy)carbonyl)-S-(triphenylmethyl)-L-cysteine | HCID 128239 | — |
| Product | HCID 69624811 | HCID 69624811 | — |
Reaction Steps
A suspension of Fmoc-S-trityl-L-cysteine (2.9 g, 5 mmol) in dry toluene (10 mL) was heated to 80° C. To this suspension was added over 20 min., di-tert-butyl-dimethylformamide acetal (4.8 mL, 20 mmol). The solution was cooled, washed with water, saturated sodium bicarbonate (2×10 mL), and evaporated. The residue was purified by flash chromatography eluting with ethyl acetate/hexanes (15/85), to give 2.2 g of N-Fluorenylmethoxycarbonyl-S-trityl-L-Cysteine-t-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06265572B1 |
|---|
| Source dataset | uspto-grants-2001_07 |
|---|
| ORD ID | ord-2248f7e9bb0344188d7bfea7d5f34580 |
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| Source note | uspto-grants-2001_07 |
|---|
