反应详情

A solution of 5-(3-benzyloxy-4-methoxy-phenyl)-3-(3-pyrrolidin-1-ylmethyl-phenyl)-1H-[1,2,4]triazole hydrochloride (1:1) (300 mg, 0.63 mmol) in ethanol (80 ml) was hydrogenated (1 atm H2) with Pd/C (10%, 50 mg) at 20° C. overnight. The catalyst was filtered off, the solvent volume was reduced to ca. 5 ml and the resulting product recrystallized. After drying under high vaccum at 40° C. for 8 hrs. the title compound was obtained (152 mg, 63% yield) as a light yellow solid. MS: m/e=351.4 (M+H+).

1. customat 20° C.
2. customovernight
3. filtrationThe catalyst was filtered off
4. customthe resulting product recrystallized
5. customAfter drying under high vaccum at 40° C. for 8 hrs