HCID 21180499, compound → HCID 9861789, compound

Participants

Reaction Steps

A solution of 3-[2-(3,4-dichloro-phenyl)-3H-imidazol-4-yl]-benzonitrile (4.1 g, 13 mmol), in THF (130 ml) was slowly added to an ice-cooled mixture of lithium aluminum hydride (0.99 g, 26 mmol) in THF (130 ml). The mixture was stirred for 30 min. at r.t., then saturated Seignette-salt solution (5 ml) was added slowly and stirring was continued for 30 min. The precipitate was filtered and the organic phase evaporated and chromatographed over SiO2 with CH2Cl2—CH3OH—NH4OH (140:10:1) to obtain 3-[2-(3,4-dichloro-phenyl)-3H-imidazol-4-yl]-benzylamine (1.77 g, 43%) as a foam. The hydrochloride salt was then prepared which was crystallized to an off-white solid. Mp. >250° C. (MeOH/Et2O), MS: m/e=318 (M+H+).

Provenance & Evidence