Dimethylamine → HCID 21180452, compound

HRID 1386935Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:17]3[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=3)[CH:20]=O)[N:12]([CH2:14][CH2:15][OH:16])[N:13]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:25][NH:26][CH3:27]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:17]3[CH:24]=[CH:23][CH:22]=[C:19]([CH2:20][N:26]([CH3:27])[CH3:25])[CH:18]=3)[N:12]([CH2:14][CH2:15][OH:16])[N:13]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 21717715HCID 21717715, compound

Product 1

HCID 21180452HCID 21180452, compound

Procedure

Using 3-[5-(3,4-dichloro-phenyl)-2-(2-hydroxy-ethyl)-2H-[1,2,4]triazol-3-yl]-benzaldehyde and dimethylamine the title compound was afforded as a crude product which was chromatographed over SiO2 (Merck 230-400 mesh) using CH2Cl2/(2M NH3 in MeOH) 95:5, before salt preparation. The pure titled compound was obtained as a off-white amorphous foam (67.7% yield) after evaporation of all solvents under reduced pressure followed by drying under high vacuum (0.05 mmHg) at 50° C. for 2 h, MS: m/e=391.2 (M+H+).

Sources & evidence

ORD record: ord-589c1fc0f1234c4abfd6eceedbc22c7b
Source dataset: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06265426B1

Reaction notes

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