Ethyl Acetate → HCID 178477984, compound

Participants

Reaction Steps

A mixture of 2-(3,4-dichloro-phenyl)-4,5-diiodo-lH-imidazole (0.93 g, 2.0 mmol) and sodium sulfite (1.01 g, 8.0 mmol) in ethanol (33 ml) and water (8 ml) was refluxed for 24 h. After addition of EtOAc (200 ml) and brine (20 ml) the organic layer was separated, then dried with Na2SO4, evaporated and chromatographed over SiO2 with EtOAc-hexane (6:1) to obtain 2-(3,4-dichloro-phenyl)-4-iodo-1H-imidazole (0.57 g, 84%) as a solid mass. Mp. 206-207° C. (EtOAc/hexane), MS: m/e=338 (M+).

Provenance & Evidence