Ethyl Acetate → HCID 21180499, compound

Participants

Reaction Steps

A solution of 2-(3,4-dichloro-phenyl)-4-iodo-1H-imidazole (1.69 g, 5 mmol) and palladium tetrakis(triphenylphosphine) (0.29 g, 0.25 mmol) in toluene (25 ml) was stirred at r.t. for 15 min. 3-cyanophenylboronic acid (0.74 g, 5 mmol) and 2M K2CO3 solution (5 ml) was then added and the resulting mixture refluxed for 24 h. EtOAc (200 ml) was added and the organic phase was dried (Na2SO4), solvent eaporated and the residue chromatographed over SiO2 with EtOAc-hexane=1:1 to give 3-[2-(3,4-dichloro-phenyl)-3H-imidazol-4-yl]-benzonitrile (0.14 g, 9%) as a colorless mass. MS: m/e=313 (M+).

Provenance & Evidence