Methyl iodide → HCID 21717724, compound

HRID 1386959Notes

Reaction equation

[O:1]1CCO[CH:2]1[C:6]1[CH:7]=[C:8]([C:12]2[N:16]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([F:25])[CH:18]=3)[NH:14][N:13]=2)[CH:9]=[CH:10][CH:11]=1.[CH3:26]I>>[F:25][C:19]1[CH:18]=[C:17]([C:15]2[N:16]=[C:12]([C:8]3[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=3)[CH:2]=[O:1])[N:13]([CH3:26])[N:14]=2)[CH:22]=[CH:21][C:20]=1[O:23][CH3:24]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 21717705HCID 21717705, compound

Product 1

HCID 21717724HCID 21717724, compound

Procedure

Using 3-(3-[1,3]dioxolan-2-yl-phenyl)-5-(3-fluoro-4-methoxy-phenyl)-1H-[1,2,4]triazole (mixture of tautomers) and methyl iodide the title compound was obtained as an orange solid (34% yield), MS: m/e=311.1 (M+).

Sources & evidence

ORD record: ord-202069446200489792650809fa8dcf4c
Source dataset: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06265426B1

Reaction notes

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