Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1386972Generated: October 27, 2026

Benzo(B)Thiophene-2-Boronic Acid → 2-[4-[2-(1-Pyrrolidinyl)ethoxy)phenyl]benzo[b]thiophene

https://huagongshe.com/reaction/1386972

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzo(B)Thiophene-2-Boronic AcidHCID 2359—
ReactantN-(2-(p-bromophenoxy)ethyl)pyrrolidineHCID 70657—
Product2-[4-[2-(1-Pyrrolidinyl)ethoxy)phenyl]benzo[b]thiopheneHCID 1066370876%

Reaction Steps

By essentially following the procedure detailed in Example 1, Part B, the title compound was prepared from benzo[b]thiophene-2-boronic acid and 1-[2-(4-bromophenoxy)ethyl]pyrrolidine in 76% yield as a white solid following flash chromatography (SiO2; 36:4:60 THF-TEA-hexanes).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06265575B1
Source datasetuspto-grants-2001_07
ORD IDord-38cf0729890d4ec3aabc476475b6675e
Source noteuspto-grants-2001_07