2-(4-Methoxyphenyl)benzothiophene → HCID 21182744, compound

HRID 1386974Notes

Reaction equation

HRID 1386974 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[CH:10]=2)=[CH:5][CH:4]=1.Cl.[N:19]1([CH2:24][CH2:25][CH2:26][C:27]2[CH:35]=[CH:34][C:30]([C:31](O)=[O:32])=[CH:29][CH:28]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1>>[N:19]1([CH2:24][CH2:25][CH2:26][C:27]2[CH:28]=[CH:29][C:30]([C:31]([C:10]3[C:11]4[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=4[S:13][C:9]=3[C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)=[O:32])=[CH:34][CH:35]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 41373912-(4-Methoxyphenyl)benzothiopheneHCID 69833807HCID 69833807, compound

Product 1

HCID 21182744HCID 21182744, compoundYield 33%

Procedure

By essentially following the procedure outlined in Example 2, Part C, the title compound was prepared from 2-(4-methoxyphenyl)benzo[b]thiophene (Example 3; Part A) and 4-[3-(1-pyrrolidinyl)propyl]benzoic acid hydrochloride in 33% yield as a viscous oil.

Sources & evidence

ORD record
ord-01ff1f8a8c26404190765e0f0b662ab2
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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