HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloronicotinic acid → 2-(4-Methoxyphenyl)benzo[b]thiophen-3-yl 6-chloropyrid-3-yl ketone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Reactant | 2-(4-Methoxyphenyl)benzothiophene | HCID 4137391 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-Methoxyphenyl)benzo[b]thiophen-3-yl 6-chloropyrid-3-yl ketone | HCID 10809759 | 31% |
Reaction Steps
By essentially following the procedure detailed in Example 1, Part C, the title compound was prepared from 6-chloronicotinic acid and 2-(4-methoxyphenyl)benzo[b]thiophene (Example 3, Part A) in 31% yield as a yellow solid following flash chromatography (SiO2; CH2Cl2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265575B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-d9bb777a10644bfe92d221b27d71541e |
| Source note | uspto-grants-2001_07 |