HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-[2-(1-Pyrrolidinyl)ethoxy]phenyl 2-[6-[2-(1-Pyrrolidinyl)ethoxy]pyrid-3-yl]benzo[b]-thiophen-3-yl Ketone Dioxalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride | HCID 13174868 | — |
| Reactant | 5-(Benzo[b]thiophen-2-yl)pyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether | HCID 21182907 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-[2-(1-Pyrrolidinyl)ethoxy]phenyl 2-[6-[2-(1-Pyrrolidinyl)ethoxy]pyrid-3-yl]benzo[b]-thiophen-3-yl Ketone Dioxalate | HCID 86757082 | 30% |
Reaction Steps
By essentially following the procedure detailed in Example 1, Part C, the title compound was prepared from 5-(benzo[b]thiophen-2-yl)pyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether (Part B) and 4-[2-(1-pyrrolidinyl)ethoxy]benzoic acid hydrochloride in 30% yield as a solid following flash chromatography (SiO2; 5% MeOH in CHCl3) The free base was converted to the dioxalate salt according to the conditions outlined in Example 1, Part C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265575B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-f7c6834203724248a5c0b690a468b0dc |
| Source note | uspto-grants-2001_07 |