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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1387015Generated: October 27, 2026

6-Chloronicotinic acid → 6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 6-Chloropyrid-3-yl Ketone

https://huagongshe.com/reaction/1387015

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Chloronicotinic acidHCID 79222—
Reactant6-Methoxy-2-[4-(2-(1-pyrrolidinyl)ethoxy)phenyl]benzo[b]thiopheneHCID 10689420—
Product6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 6-Chloropyrid-3-yl KetoneHCID 2118295951%

Reaction Steps

The title compound was prepared from 6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene (Example 1, Part B) and 6-chloronicotinic acid in 51% yield (based on 6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene) by essentially following the procedures described in Example 1, Part C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06265575B1
Source datasetuspto-grants-2001_07
ORD IDord-a04b7a5c1b7f474890a63fec9ecd34f5
Source noteuspto-grants-2001_07