Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1387016Generated: October 31, 2026

1-Pyrrolidineethanol → 6-Methoxy-2-[4-[2-(1pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 6-[2-(1-Pyrrolidinyl)ethoxy]pyrid-3-yl Ketone

https://huagongshe.com/reaction/1387016

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-PyrrolidineethanolHCID 76288—
Reactant6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 6-Chloropyrid-3-yl KetoneHCID 21182959—
Product6-Methoxy-2-[4-[2-(1pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 6-[2-(1-Pyrrolidinyl)ethoxy]pyrid-3-yl KetoneHCID 2118275984%

Reaction Steps

The title compound was prepared in 84% yield from 6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 6-chloropyrid-3-yl ketone (Part A) and 1-(2-hydroxyethyl)pyrrolidine by essentially following the procedures described in Example 9, Part B.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06265575B1
Source datasetuspto-grants-2001_07
ORD IDord-9b159adfa2534396a8ebcbef120c9027
Source noteuspto-grants-2001_07