4-Fluoro-3-(trifluoromethyl)benzoyl Chloride → HCID 21182643, compound

HRID 1387023Notes

Reaction equation

HRID 1387023 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]2[CH:16]=[C:15]([N:17]([CH3:19])[CH3:18])[S:14][C:13]=2[CH:20]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][C:23]=1[C:31]([F:34])([F:33])[F:32]>>[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([C:16]2[C:12]3[CH:11]=[CH:10][C:9]([O:8][CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[CH:20][C:13]=3[S:14][C:15]=2[N:17]([CH3:18])[CH3:19])=[O:27])=[CH:24][C:23]=1[C:31]([F:32])([F:33])[F:34]

Participants

3

Reactant 2

HCID 1442534-Fluoro-3-(trifluoromethyl)benzoyl ChlorideHCID 106129946-Benzyloxy-2-dimethylaminobenzo[b]thiophene

Product 1

HCID 21182643HCID 21182643, compoundYield 93%

Procedure

The title compound was prepared in 93% yield from 6-benzyloxy-2-(dimethylamino)benzo[b]thiophene and 4-fluoro-3-(trifluoromethyl)benzoyl chloride by essentially following the procedure outlined in Example 81, Part C, and Example 85, Part B.

Sources & evidence

ORD record
ord-65f95a3312fb413e92312aa1b14d2c6f
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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