4-Fluorobenzoyl chloride → HCID 21182689, compound

HRID 1387027Notes

Reaction equation

HRID 1387027 reaction equation
[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:6]2[S:7][C:8]([C:10]3[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH2:18][N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)=[CH:12][CH:11]=3)=[CH:9][C:5]=2[CH:4]=1.[F:26][C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1>>[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:6]2[S:7][C:8]([C:10]3[CH:11]=[CH:12][C:13]([O:16][CH2:17][CH2:18][N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)=[CH:14][CH:15]=3)=[C:9]([C:31]([C:30]3[CH:34]=[CH:35][C:27]([F:26])=[CH:28][CH:29]=3)=[O:32])[C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 21182680HCID 21182680, compound

Product 1

HCID 21182689HCID 21182689, compound

Procedure

The title compound was prepared by essentially following the procedure detailed in Example 1, Part C, from 5-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene (Part C) and 4-fluorobenzoyl chloride. The crude product was purified by flash chromatography (silica gel, 55:42:3 THF-hexanes-Et3N) to afford 2.11 g (4.44 mmol, 71%) of a yellow semi-solid.

Workup

  1. customThe crude product was purified by flash chromatography (silica gel, 55:42:3 THF-hexanes-Et3N)

Sources & evidence

ORD record
ord-0dc7cd54f4ba444495794cd4af100464
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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