HCID 18397572, compound → HCID 20666774, compound

HRID 1387029Notes

Reaction equation

HRID 1387029 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16](F)=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)=[CH:22][CH:21]=3)[S:8][C:7]=2[CH:34]=1.[N:35]1([C@@H:41]2[CH2:45][CH2:44][CH2:43][C@H:42]2[OH:46])[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1>>[N:35]1([C@@H:41]2[CH2:45][CH2:44][CH2:43][C@H:42]2[O:46][C:16]2[CH:17]=[CH:18][C:13]([C:11]([C:10]3[C:6]4[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:34][C:7]=4[S:8][C:9]=3[C:20]3[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)=[CH:22][CH:21]=3)=[O:12])=[CH:14][CH:15]=2)[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 18397572HCID 18397572, compoundHCID 21182699HCID 21182699, compound

Product 1

HCID 20666774HCID 20666774, compoundYield 70%

Procedure

The title compound was prepared in 70% yield by essentially following the procedures outlined in Example 72, Part E, from 4-fluorophenyl 6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl ketone (Example 59, Part A) and (±)-trans-2-(1-piperidyl)cyclopentanol (Part A).

Sources & evidence

ORD record
ord-830e73d3da244129bba35348aa20b972
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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