HRID1387030

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15560800

未命名化合物

结构：COc1ccc2c(C(=O)c3ccc(F)cc3)c(-c3ccc(OCCN4CCCC4)cc3)sc2c1

HCID21182699

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)[C@@H]1CCCC[C@H]1Oc1ccc(C(=O)c2c(-c3ccc(OCCN4CCCC4)cc3)sc3cc(OC)ccc23)cc1

HCID18397525

未命名化合物

收率 67%

PROCEDURE

实验过程

The title compound was prepared in 67% yield by essentially following the procedures outlined in Example 72, Part E, from 4-fluorophenyl 6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl ketone (Example 59, Part A) and (±)-trans-2-(diethylamino)cyclohexanol (Part A).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-71e3a6ad4e71429fba0cc0256f29a61e
来源数据集: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06265575B1
来源说明: uspto-grants-2001_07

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16](F)=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)=[CH:22][CH:21]=3)[S:8][C:7]=2[CH:34]=1.[CH2:35]([N:37]([CH2:45][CH3:46])[C@@H:38]1[CH2:43][CH2:42][CH2:41][CH2:40][C@H:39]1[OH:44])[CH3:36]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:44][C@@H:39]4[CH2:40][CH2:41][CH2:42][CH2:43][C@H:38]4[N:37]([CH2:45][CH3:46])[CH2:35][CH3:36])=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)=[CH:22][CH:21]=3)[S:8][C:7]=2[CH:34]=1