HuagongsheHuagongshe Chemistry Print Report · For research reference only
trans-2-Piperidinocyclohexan-1-ol → (+/-)-6-Benzyloxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 3-Methoxy-4-[[trans-2-(1-piperidyl)cyclohexyl]oxy]phenyl Ketone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | trans-2-Piperidinocyclohexan-1-ol | HCID 111310 | — |
| Reactant | 6-Benzyloxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 3-Methoxy-4-hydroxyphenyl Ketone | HCID 18318471 | — |
| Product | (+/-)-6-Benzyloxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 3-Methoxy-4-[[trans-2-(1-piperidyl)cyclohexyl]oxy]phenyl Ketone | HCID 18397537 | 72% |
Reaction Steps
The title compound was prepared in 72% yield by essentially following the procedures outlined in Example 20, Part B, from 6-benzyloxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-hydroxy-3-methoxyphenyl ketone (Example 81, Part F) and (±)-trans-2-(1-piperidyl)cyclohexanol (Example 20, Part A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265575B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-16a9177237c24fc087554b81cd0fad9f |
| Source note | uspto-grants-2001_07 |