rac-(1R,2R)-2-(dimethylamino)cyclohexan-1-ol → HCID 18397571, compound

HRID 1387037Notes

Reaction equation

HRID 1387037 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[O:4][N:3]=1.[CH3:11][N:12]([CH3:20])[C@@H:13]1[CH2:18][CH2:17][CH2:16][CH2:15][C@H:14]1O>>[CH3:11][N:12]([CH3:20])[C@@H:13]1[CH2:18][CH2:17][CH2:16][CH2:15][C@H:14]1[O:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 15560793rac-(1R,2R)-2-(dimethylamino)cyclohexan-1-olHCID 178498603HCID 178498603, compound

Product 1

HCID 18397571HCID 18397571, compoundYield 73%

Procedure

The title compound was prepared in 73% yield by essentially following the procedures outlined in Example 20, Part B from methyl 3-hydroxyisoxazole-5-carboxylate and (±)-trans-2-(dimethylamino)cyclohexanol (Example 79, Part A).

Sources & evidence

ORD record
ord-16785b94aadd456ab34a637290c6065d
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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