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HRID 1387047作成日：2026年10月25日

trans-2-Piperidinocyclohexan-1-ol → 2-Dimethylamino-5-fluoro-6-methoxybenzo[b]thiophene-3-yl 4-[[trans-2-(1-Piperidyl)cyclohexyl]oxy]phenyl Ketone

https://huagongshe.com/reaction/1387047

反応式

関与物質

役割名称HCID仕込み量
反応物trans-2-Piperidinocyclohexan-1-olHCID 111310—
反応物2-Dimethylamino-5-fluoro-6-methoxybenzo[b]thiophene-3-yl 4-Nitrophenyl KetoneHCID 21182875—
生成物2-Dimethylamino-5-fluoro-6-methoxybenzo[b]thiophene-3-yl 4-[[trans-2-(1-Piperidyl)cyclohexyl]oxy]phenyl KetoneHCID 53666605—

反応手順

The title compound was prepared in 51% from 2-dimethylamino-5-fluoro-6-methoxybenzo[b]thiophene-3-yl 4-nitrophenyl ketone (Example 117, Part C) and (±)-trans-2-(1-piperidyl)cyclohexanol by essentially following the procedure detailed in Example 117, Part D.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06265575B1
出典データセットuspto-grants-2001_07
ORD IDord-7bad7532cf054d7bb1aea2a609e9e232
出典メモuspto-grants-2001_07