HRID1387064

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7902

Dimethylaminoethanol

C4H11NO

结构：O=C(c1ccc(F)cc1)c1c(-c2ccc(OCCN3CCCC3)cc2)sc2ccccc12

HCID10718205

未命名化合物

HCID21873181

未命名化合物

PRODUCTS

生成物

结构：CN(C)CCOc1ccc(C(=O)c2c(-c3ccc(OCCN4CCCC4)cc3)sc3ccccc23)cc1.O=C(O)C(=O)O.O=C(O)C(=O)O

HCID86757214

未命名化合物

收率 55%

PROCEDURE

实验过程

The title compound was prepared from 4-fluorophenyl 2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl ketone (Example 132, Part A) and 2-(dimethylamino)ethanol in 55% yield after radial chromatography (SiO2; gradient of 98:1.5:0.5 to 95:4:1 CHCl3—MeOH—NH4OH) by essentially following the procedure described in Example 132, Part B.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d91d3e8f3f544f8a874b983da8ad3612
来源数据集: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06265575B1
来源说明: uspto-grants-2001_07

反应 SMILES

[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[S:19][C:18]4[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=4[C:16]=3[C:24]([C:26]3[CH:31]=[CH:30][C:29](F)=[CH:28][CH:27]=3)=[O:25])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:33][N:34]([CH3:38])[CH2:35][CH2:36][OH:37].C(Cl)(Cl)Cl.[CH3:43][OH:44].[NH4+].[OH-:46]>>[C:24]([OH:25])(=[O:37])[C:43]([OH:46])=[O:44].[C:36]([OH:37])(=[O:8])[C:43]([OH:46])=[O:44].[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[S:19][C:18]4[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=4[C:16]=3[C:24]([C:26]3[CH:31]=[CH:30][C:29]([O:37][CH2:36][CH2:35][N:34]([CH3:38])[CH3:33])=[CH:28][CH:27]=3)=[O:25])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1