4-Fluorobenzoyl chloride → HCID 21182688, compound

HRID 1387068Notes

Reaction equation

HRID 1387068 reaction equation
[F:1][C:2]1[C:7]2[S:8][C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)=[CH:13][CH:12]=3)=[CH:10][C:6]=2[CH:5]=[CH:4][C:3]=1[O:25][CH3:26].[F:27][C:28]1[CH:36]=[CH:35][C:31]([C:32](Cl)=[O:33])=[CH:30][CH:29]=1>>[F:27][C:28]1[CH:36]=[CH:35][C:31]([C:32]([C:10]2[C:6]3[CH:5]=[CH:4][C:3]([O:25][CH3:26])=[C:2]([F:1])[C:7]=3[S:8][C:9]=2[C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][N:20]3[CH2:21][CH2:22][CH2:23][CH2:24]3)=[CH:15][CH:16]=2)=[O:33])=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 21182868HCID 21182868, compound

Product 1

HCID 21182688HCID 21182688, compoundYield 41%

Procedure

The title compound was prepared in 41% yield from 7-fluoro-6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene (Part D) and 4-fluorobenzoyl chloride by essentially following the procedure outlined in Example 129, Part A.

Sources & evidence

ORD record
ord-1c117e17287f49c986fe3da705ab97dd
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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