反应详情

To 4-[3-bromo-4-[(1-pyrrolidinyl)methyl]phenyl 6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl ketone (Example 137; part C) (0.2 g; 0.32 mmol) in 3.0 mL of THF was added 18.4 mg (0.48 mmol) of LAH at 0° C. The bath was removed and the mixture was stirred for 1 h. Hydrolysis was effected by addition of 1 drop of water, 1 drop of 5N NaOH, and 3 drops of water, followed by stirring for 1 h. The mixture was filtered, the filtrate was concentrated and, the intermediate carbinol was dried in vacuo for 25 min. The carbinol was dissolved in methylene chloride (3.0 mL) under argon atmosphere and cooled in an ice-water bath. Triethylsilane (0.36 mL; 2.26 mmol) was added, followed by dropwise addition of 0.25 mL (3.23 mmol) of TFA. Upon completion of addition of TFA, the bath was removed and stirring was continued for 2 h. Saturated aqueous sodium bicarbonate (25 mL) was added, and extraction was carried out with EtOAc. The combined organics were washed with brine and dried by passage through sodium sulfate. The title compound (0.14 g; 72% yield) was isolated as a colorless oil by flash chromatography on silica gel eluting with a gradient of EtOAc(100-95%)/Et3N(0-5%).

1. customThe bath was removed
2. customHydrolysis
3. stirringby stirring for 1 h
4. filtrationThe mixture was filtered
5. concentrationthe filtrate was concentrated
6. dry with materialthe intermediate carbinol was dried in vacuo for 25 min
7. dissolutionThe carbinol was dissolved in methylene chloride (3.0 mL) under argon atmosphere
8. temperaturecooled in an ice-water bath
9. customthe bath was removed
10. stirringstirring
11. waitwas continued for 2 h
12. additionSaturated aqueous sodium bicarbonate (25 mL) was added
13. extractionextraction
14. washThe combined organics were washed with brine
15. dry with materialdried by passage through sodium sulfate