6-Methoxy-2-[4-(2-(1-pyrrolidinyl)ethoxy)phenyl]benzo[b]thiophene → HCID 21182644, compound

HRID 1387076Notes

Reaction equation

HRID 1387076 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[CH2:12][N:13]([CH3:15])[CH3:14])[C:5]([O:7]C)=O.[CH3:16][O:17][C:18]1[CH:19]=[CH:20][C:21]2[CH:25]=[C:24]([C:26]3[CH:31]=[CH:30][C:29]([O:32][CH2:33][CH2:34][N:35]4[CH2:39][CH2:38][CH2:37][CH2:36]4)=[CH:28][CH:27]=3)[S:23][C:22]=2[CH:40]=1>>[CH3:16][O:17][C:18]1[CH:19]=[CH:20][C:21]2[C:25]([C:5]([C:4]3[CH:9]=[CH:10][C:11]([CH2:12][N:13]([CH3:15])[CH3:14])=[C:2]([Br:1])[CH:3]=3)=[O:7])=[C:24]([C:26]3[CH:27]=[CH:28][C:29]([O:32][CH2:33][CH2:34][N:35]4[CH2:39][CH2:38][CH2:37][CH2:36]4)=[CH:30][CH:31]=3)[S:23][C:22]=2[CH:40]=1

Participants

3

Reactant 2

HCID 106894206-Methoxy-2-[4-(2-(1-pyrrolidinyl)ethoxy)phenyl]benzo[b]thiopheneHCID 21182833HCID 21182833, compound

Product 1

HCID 21182644HCID 21182644, compoundYield 66%

Procedure

By essentially following the procedure used to prepare Example 137, Part C, the title compound was prepared from methyl 3-bromo-4-[(dimethylamino)methyl]benzoate (Part A) and 6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene (Example 1, Part B) in 66% yield.

Workup

  1. customto prepare Example 137, Part C

Sources & evidence

ORD record
ord-73c32480eede4f6f9178f0f4c79c8978
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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