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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1387108Generated: November 1, 2026

1-(2-Chloroethyl)pyrrolidine hydrochloride → 1-[2-[2-Methoxy-4-[[6-benzyloxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl]methyl]phenoxy]ethyl]pyrrolidine

https://huagongshe.com/reaction/1387108

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Chloroethyl)pyrrolidine hydrochlorideHCID 81668—
Reactant6-Benzyloxy-3-[(3-methoxy-4-hydroxyphenyl)methyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiopheneHCID 18318482—
Product1-[2-[2-Methoxy-4-[[6-benzyloxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl]methyl]phenoxy]ethyl]pyrrolidineHCID 2118266930%

Reaction Steps

The title compound was prepared in 30% yield from 6-benzyloxy-3-[(3-methoxy-4-hydroxyphenyl)methyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene (Part E) and 1-(2-chloroethyl)pyrrolidine hydrochloride by a method similar to that outlined in Example 188, Part A.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06265575B1
Source datasetuspto-grants-2001_07
ORD IDord-140843ee293b4f0c8199972c386f6a3d
Source noteuspto-grants-2001_07