Trimethylsilyl iodide → HCID 21182795, compound

Participants

Reaction Steps

The 379 mg of 6-benzyloxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 3-[(methoxycarbonyl)(methyl)amino]-4-(1-pyrrolidinylmethyl)phenyl ketone (Part G) was dissolved in 5.5 mL of dry CH2Cl2. To the solution was added 0.31 mL of trimethylsilyl iodide. The reaction mixture was stirred for 5.5 h. The reaction was quenched with 0.3 mL of MeOH and the mixture was concentrated to dryness under reduced pressure. Purification by flash chromatography (silica gel, 5% to 8% [10% conc NH4OH/MeOH]/CH2Cl2) afforded 130 mg (0.201 mmol, 37%) of a yellow foam.

Provenance & Evidence