Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → HCID 178465598, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethanimidic acid, ethyl ester, hydrochloride (1:1) | HCID 2724290 | — |
| 반응물 | 2-[4-(2-Aminoethyl)phenyl]-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene | HCID 22462716 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | HCID 178465598 | HCID 178465598 | — |
반응 단계
2-[4-(2-Aminoethyl)phenyl]-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene (100 mg) was dissolved in dichloromethane:methanol (2:5, 7.0 mL), treated with triethylamine (0.2 mL) and ethyl acetimidate hydrochloride (135 mg) sequentially and allowed to stir at ambient temperature for 4 h. The reaction mixture was concentrated and fractionated by column chromatography with NH4OH:MeOH:—EtOAc (10:20:70) to afford the title compound (51 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06265575B1 |
| 출처 데이터셋 | uspto-grants-2001_07 |
| ORD ID | ord-0a0a2881be9f40ffbd9d1eeef0cc79bb |
| 출처 메모 | uspto-grants-2001_07 |