HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-1-propanol → 71347-90-5
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| Reactant | benzyl N-(2-hydroxyethyl)carbamate | HCID 280458 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | HCID 86757220 | HCID 86757220 | — |
| Product | 71347-90-5 | HCID 3090849 | — |
Reaction Steps
The propanolamine compound prepared above (1.0 eq), N-(benzyloxycarbonyl)ethanolamine (25 eq) and camphorsulfonic acid (1.0 eq) are dissolved in a small amount of dioxane-DMF-DMSO (10:2:1) and stirred at room temperature for about 24 hours. The mixture is neutralized by the addition of aqueous sodium bicarbonate and purified by preparative HPLC (C18 “ZORBAX”, step gradient starting at 70/30:H2O/CH3CN/0.1% TFA). The appropriate fractions are combined, frozen and lyophilized to give solid (MW=1621.66).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06268338B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-24f0246d17ef4387b2f4f1c609615fb6 |
| Source note | uspto-grants-2001_07 |