Bromine → 6-Bromo-5-methyl-1H-benzo[d][1,3]oxazin-2(4H)-one

Participants

Reaction Steps

To a solution of 5-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one (0.695 g, 4.3 mmol) in acetic acid (5 mL), Br2 (0.805 g=5 mmol) solution in TFA (5 mL)+acetic acid (5 mL) was added at 10° C. Reaction mixture was stirred for 2 hours and poured over ice water. Yellow precipitate was filtered and dried at 120° C.

Provenance & Evidence