HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1387278Generated: October 25, 2026
Iodine → 5-Iodo-4-methyl-3-nitro-1,2-dihydropyridin-2-one
https://huagongshe.com/reaction/1387278
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Hydroxy-4-methyl-3-nitropyridine | HCID 345370 | — |
| Reactant | Sodium Iodate | HCID 23675764 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 5-Iodo-4-methyl-3-nitro-1,2-dihydropyridin-2-one | HCID 21706514 | — |
Reaction Steps
To a solution of 4-methyl-3-nitro-2-pyridone (2.00 g, 13 mmol) in acetic acid (12 mL) and concentrated sulfuric acid (1.6 ml,) was added iodine (1.32 g) and sodium iodate (0.55 g). The mixture was heated at 75° C. for 2.5 hours and then stirred at rt overnight. Water (100 mL) was added, and the precipitated 5-iodo-4-methyl-3-nitro-2-pyridone was collected by filtration (2.97 g, 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06268365B1 |
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| Source dataset | uspto-grants-2001_07 |
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| ORD ID | ord-4e8af721267749e8b617049bd221cc3a |
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| Source note | uspto-grants-2001_07 |
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